| 초록 |
Combination therapy has been great attention due to its high therapeutic effects to various cancers with poor prognosis. Among them, chemotherapy combined with photodynamic therapy is considered as one of the outstanding strategies. However, abnormal increase of angiogenesis is induced by photodynamic therapy. To complement this, anti-VEGF siRNA nanoparticle containing chemotherapeutic drug was used in this study. Moreover, siRNA damage caused by reactive oxygen species could be prevented by coating with biocompatible polymers. Through this improvements, we have successfully developed the triple combination therapy system. Neovascularization can be overcome while maintaining the advantages of the nanoparticle/microbubble complex such as deep tissue penetration. The results showed high therapeutic efficiency both in in vitro and in vivo. In conclusion, the complex of siRNA nanoparticle with drug and microbubbles with photosensitizer can be the best strategy for advanced cancer therapy. |
