| 초록 |
Gold nanorods (AuNRs) have attracted much attention as the potential agent for hyperthermia therapy. However, gold nanorods cannot be used in the biomedical field because of the toxic cetyltrimethylammonium bromide (CTAB), which is used as the stabilizing agent during the preparation of gold nanorods. To reduce cytotoxicity and to improve stability of the gold nanorods in physiological condition, AuNRs were coated with glycol chitosan(GC) or heparin. Heparin and GC were conjugated with 3,4-dihydroxyphenylalanine(DOPA), one of the major components of the mussel adhesive polymer, and its derivatives, and then applied to encapsulate AuNRs. AuNRs were characterized by zeta-potential, dynamic light scattering, 1H NMR, HR-TEM, and stability test in PBS. The AuNRs were stable in the water and PBS for several days. |
