| 학회 |
한국공업화학회 |
| 학술대회 |
2006년 가을 (11/10 ~ 11/11, 경희대학교(수원캠퍼스)) |
| 권호 |
10권 2호 |
| 발표분야 |
우수논문 |
| 제목 |
Chitosan nanoparticles based on Polyelctrolyte Complexes of All-Trans Retinoic Acid and methoxy poly (ethylene glycol)-grafted-chitosan |
| 초록 |
We synthesized methoxy poly(ethylene glycol)-grafted chitosan (ChitoPEG) copolymer to prepare RA-encapsulated polymeric micelle. RA-encapsulated polymeric micelle of ChitoPEG copolymer is 100-500 nm in particle size and has spherical shape when observed by TEM. In 1H NMR study, the specific peaks of RA and chitosan as a drug carrying innercore disappeared at D2O and only the specific peak of MPEG was observed, while specific peaks of MPEG, RA, and chitosan appeared at DMSO. This indicates that RA/ChitoPEG ion complexes are composed of polymeric micelle with a core-shell structure, and that free drug does not exist on the polymeric micelles formulations. |
| 저자 |
김동곤1, 나재운1, 정영일1, 장미경1, 권중근2, 최창용1
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| 소속 |
1순천대, 2조선이공대 |
| 키워드 |
Low molecular water-soluble chitosan; all-trans retinoic acid; polyion complex; nanoparticles; anticancer drug |
| E-Mail |
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