| 학회 |
한국재료학회 |
| 학술대회 |
2008년 가을 (11/07 ~ 11/07, 차세대융합기술연구원) |
| 권호 |
14권 2호 |
| 발표분야 |
나노생체재료 |
| 제목 |
In vitro biocompatibility of a reinforced Calcium Phosphate – Calcium Sulfate Injectable bone substitute |
| 초록 |
In recent years, it has been tried to develop the efficacy and bioactivity of Calcium Phosphate-Calcium Sulfate injectable bone substitute (IBS) by reinforcing them through varying the amount in its compositions and relative concentrations. In this study, the biocompatibility of a reinforced Calcium Phosphate-Calcium Sulfate injectable bone substitute (IBS) was evaluated which consisted of solution chitosan and citric acid as liquid phase and tetra calcium phosphate (TTCP), dicalcium phosphate anhydrous (DCPA) and Hydroxypropyl-Methyl-Cellulose (HPMC) powder as the solid phase. The mass content of HPMC in liquid phase was varied in arrays of 0%, 2%, 3% and 4% to investigate the effect of HPMC on setting times, compressive strength and in vitro biocompatibolity. The in vitro experiments with simulated body fluid (SBF) confirmed the formation of apatite on sample surface after 14 and 28 days of incubation in SBF. The pH of each sample went to its peak after 7 days of incubation in SBF and then tends to rewind back gradually with the increasing incubation period. MG-63 cells were found to maintain their phenotype on samples and SEM micrograph confirmed that cellular attachment was well. In vitro cytotoxicity tests by an extract dilution method showed that the IBS was cytocompatible for fibroblast L-929. |
| 저자 |
Md. Anirban Jyoti1, Van Viet Thai2, Young Hee Kim1, In-Seon Byun2, Byong-Taek Lee1, Ho-Yeon Song2
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| 소속 |
1Soonchunhyang Univ., 2school of medicine |
| 키워드 |
injectable bone substitute; HPMC; Biocompatibility; SBF
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| E-Mail |
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