| 학회 |
한국고분자학회 |
| 학술대회 |
2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 |
28권 1호, p.176 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation of Thermosensitive Block Copolymer Micelles Composed of Poly (ε-caprolactone) and Poly (N-isopropylacrylamide) |
| 초록 |
The synthesis and characteristics of amphiphilic block copolymers have been much interest because of he unique molecular architecture and different chemical nature. In this study, the well-defined poly (ε -caprolactone) (PCL)/poly (N-isopropylacrylamide) (PNIPAAm) diblock copolymers were synthesized through combining radical polymerization of NIPPAAm and the controlled coordination-insertion ring-opening polymerization of CL using an aluminum alkoxide macroinitiator formed from the equimolar reaction of triethylaluminum with hydroxy-terminated PNIPAAm (PNIPAAm-OH). Molecular characterization of PCL/PNIPAAm diblock copolymers was confirmed through 1H-NMR spectrophotometer, FT-IR spectrophotometer and gel permeation chromatograhp analysis. Polymeric micelles composed of PCL as a hydrophobic core and PNIPAAm as a hydrophilic shell were prepared by a diafiltration method. The sizes and shapes of the thermosensitive micelles were investigated with a dynamic light scattering spectrometer and with a transmission electron microscope.
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| 저자 |
최창용;정택웅;나재운 |
| 소속 |
순천대 |
| 키워드 |
thermosensitive block copolymer; poly(ε-caprolactone); poly (N-isopropylacrylamide)
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| E-Mail |
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