| 초록 |
This study is to overcome poor solubility of celecoxib. For that reason, celecoxib has very low bioavailability. On this account, using a solid dispersions techniques improve the low solubility. Solid dispersion was prepared with hydrophilic polymer poly-vinyl-pyrrolidone(PVP) and solubilizing agent soluplus. Characterization of solid dispersion was analyzed by using SEM, DSC, XRD and FT-IR. SEM and FT-IR was used to alalyze morphology and salt formation by chemical bond between celecoxib and polymer. DSC and XRD were used to analyze both the amorphous and crystal field of solid dispersions. The IN VITRO study presented in simulated gastric juice (pH 1.2, SLS 0.5%). The dissolution rate of prepared solid dispersion was dramatically higher than commercial drug (Celebrex®). This study says that the rate of added polymers effect the dissolution rate and prepared solid dispersion system improved the bioavailability of low solubility drug. |
