| 학회 | 한국공업화학회 |
| 학술대회 | 2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 | 21권 1호 |
| 발표분야 | (콜로이드계면화학)첨단 소재 및 바이오 기술 분야의 표면화학 연구동향 |
| 제목 | Biomedical application of microneedle technology |
| 초록 | Immunization via the skin is attractive, because, in large part, the skin is replete with antigen-presenting cells such as Langerhans and dermal dendritic cells. Arrays of metal micron-scale needles were coated with vaccines suitable for simple, manual application. Vaccinatione using microneedles generated strong antibody and cellular immune responses in mice and provided superior protection against lethal viral challenge at the main site of viral replication in the lung, as evidenced by virus clearance below the detection limit. Additionally, microneedle vaccination resulted in enhanced cellular recall responses after challenge. Apart from immunologic advantages, microneedles also offer potential logistic opportunities. Vaccination should be faster and simpler because microneedles are painless and suitable for self administration. Mass-produced microneedles would be cost-competitive with hypodermic needle and syringe. |
| 저자 | 김유천 |
| 소속 | 한국과학기술원 |
| 키워드 | Microneedle; Vaccination |
