| 학회 |
한국공업화학회 |
| 학술대회 |
2006년 가을 (11/10 ~ 11/11, 경희대학교(수원캠퍼스)) |
| 권호 |
10권 2호 |
| 발표분야 |
고분자 |
| 제목 |
Stable Vesicle Formation Containing Drug-Cyclodextrin Complexesby Association of Amphiphilic Polyelectrolytes |
| 초록 |
It has been generally known that lipid vesicles are destabilized when they contain the drugs complexed with cyclodextrins, but the present study shows that these vesicles can be stable by association of amphiphilic polyelectrolytes. Transmission electron microscope and microcalorimetry studies showed that polymer-liposome complexes containing drug-cyclodextrin complexes had a closed vesicle structure. The skin permeation experiment demonstrated that drugs solubilized by cyclodextrins were delivered better into the skin of guinea pig by using polymer-liposome complexes than by using phosphatidylcholine:Cholesterol liposomes. |
| 저자 |
임형준, 조은철, 김준오, 장이섭
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| 소속 |
(주)아모레퍼시픽 / 기술(연) |
| 키워드 |
vesicle; polyelectrolyte; polymer-liposome complex; liposome; cyclodextrin
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| E-Mail |
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