| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 | 28권 2호, p.81 |
| 발표분야 | 기능성 고분자 |
| 제목 | A Novel Fabrication Technique of Poly(L-lactic acid) Dual Pore Sized Nanocomposite Scaffold using Electrospinning and Nanoclay Reinforcement |
| 초록 | Porous biodegradable scaffolds have been studied for the application as a three-dimensional template for initial cell attachment and subsequent tissue formation both in vitro and in vivo. The scaffolds should be highly porous and the pore size should be well controlled to allow cells to be seeded and to permit the facile invasion of blood vessels for the supply of nutrients to the transplanted cells. Different fabrication techniques have been developed to control the pore size and porosity in a consistent manner in various scaffold applications. In this study, a novel scaffold fabrication technique was developed by combining electrospinning process and nanocomposite technology for the purpose of facilitaiong cell implantation and blood vessel invasion and tailoring mechanical stiffness of biodegradable scaffold. Poly(L-lactic acid) (PLLA) solution containing nano-sized montmorillonite (MMT) platelets was electrospun to provide MMT-reinforced PLLA nanocomposite fibers. The resulting nano-sized nanocomposite fibers were compression molded with particulate salts in the solid state, and subsequently the salt particles were leached out forming a three-dimensional biodegradable scaffolds, which desirably contained nano- and micro-sized dual porosity structure. |
| 저자 | 이종훈, 이윤희, 이두성, 이영관, 남재도 |
| 소속 | 성균관대 |
| 키워드 | Scaffold; nanocomposite; electrospinning |
