| 초록 |
Magnetic iron oxide nanoparticles have received much attention due to their unique properties, enabling their broad use in biomedical applications. In particular, magnetic force guided delivery systems have shown promising potential in the development of targeted drug delivery systems for brain tumor. It is well known that MIONs with larger core size tend to accumulate more efficiently at the brain tumor site. However, due to their physical size, a rapid clearance can occur by reticuloendothelial system that limits the use of these large particles in practical application. This study aims to enhance the targeted delivery and accumulation of MIONs in brain tumor by in situ formation of clusters of MIONs. To achieve this goal, MIONs modified with thiolated poly(ethylene glycol) (MIONs-PEG-SH) are prepared. When an external magnetic force is applied, the MIONs-PEG-SH rapidly form the clusters of MIONs, enhancing the accumulation and retention of MIONs in rat brain tumor model. |
