| 초록 |
We synthesized redox-sensitive LMWSC-g-LA using low molecular weight water-soluble chitosan(LMWSC) and lipoic acid(LA) with coupling agent. For the cancer therapy, doxorubicin was loaded into core of LMWSC-g-LA(LL) by hydrophobic interaction. In addition, DOX-loaded LL(LLDOX) was crosslinked by reduction of disulfide bond(-s-s-) into core with treated DTT for enhanced stability of particle. The characterization of core-crosslinked micelles were analyzed by FT-IR, 1H-NMR, DLS, TEM, and CAC. The drug release behavior was confirmed in various in-vitro environment. Moreover, cytotoxicity and antitumor effect was accomplished by MTT assay. These results suggest that LL can apply as carrier for drug delivery. This research was supported by The Leading Human Resource Training Program of Regional Neo industry through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT and future Planning(NRF-2016H1D5A1910499) |
