| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 가을 (10/30 ~ 11/01, 대전컨벤션센터) |
| 권호 |
17권 2호 |
| 발표분야 |
포스터-고분자 |
| 제목 |
A tunable fluorescence nanoplatform using BODIPY-conjugated polymer with graphene oxide for cancer detection and treatment |
| 초록 |
This paper demonstrates the development of pH and thermo-responsive fluorescent nanoparticles (NPs) composed of graphene oxide (GO) with BODIPY conjugated PEG, to trigger cancer cells detection through imaging. The NPs were well characterized by transmission electron microscope (TEM) and dynamic light scattering (DLS). Responsiveness to pH was conducted by AFM and observed an apparent thickness differences upon changes of pH. Confocal image of the NPs showed remarkable bright fluorescence at lysosomal pH while no fluorescence under physiological environment were observed enabling the NPs as a novel fluorescent probe. The NPs also revealed outstanding cell viability. Therefore, the developed NPs are novel candidate for a fluorescent probe to identify the cancer cell along with a drug carrier to treat cancer. |
| 저자 |
Tamim Mosaiab, 박성영
|
| 소속 |
한국교통대 |
| 키워드 |
BODIPY; cell imaging; drug delivery; fluorescent nanoparticles; graphene oxide
|
| E-Mail |
|
