| 학회 |
한국재료학회 |
| 학술대회 |
2018년 가을 (11/07 ~ 11/09, 여수 디오션리조트) |
| 권호 |
24권 2호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Antiviral co-delivery polymersomes by controlling surface density of cell-targeting phenylboronic acid functional groups for virus treatment |
| 초록 |
Influenza A virus (IAV), which causes one of the most contagious diseases is a global health concern, and is responsible for seasonal epidemics and pandemics. Despite great efforts towards contriving antiviral agents and drugs, a vast majority of these, especially intracellular drugs, have shown limited efficacy due to non-specificity and low viability under physiological or endosomal conditions. Polymersomes consist of phenylboronic acid (PBA) pendant group polymers (PBASomes) and can act as drug carriers; they have sialic acid-targeting property and can gain more efficient access to the intracellular space for transport of antivirals within the host cell. Amphiphilic copolymers comprising methoxy-poly(ethylene glycol)-block-poly (phenylalanine) (mPEG-b-pPhe) formed polymersomes, which encapsulated mir-323a in the core and favipiravir in the exterior layer as hydrophilic and hydrophobic antivirals, respectively. For maximizing the cellular uptake of PBASomes via receptor-mediated endocytosis, the surface density of PBA was optimized with PBA-functionalized copolymers (PBA-PEG-pPhe). Combination therapy by employing polymersomes with PBA functional groups induced a synergistic effect against H1N1 virus infection in vitro. We believe that antiviral co-delivery using this polymersome would provide better opportunities to improve transfection of therapeutic substances for IAV treatment. |
| 저자 |
박채원1, 천해진2, 염민주1, 김현욱2, 임종우3, 나운성4, 박근선3, 강아람4, 윤다연1, 김지혜2, 송대섭3, 함승주4
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| 소속 |
1연세대, 2화공생명공학과, 3고려대, 4약학대 |
| 키워드 |
<P>Polymersome; surface density optimization; phenylboronic acid; Antiviral drug delivery</P>
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| E-Mail |
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