| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Synthesis and characterization of photo-crosslinkable thermogelling methacrylated hexanoyl glycol chitosan for biomedical applications |
| 초록 |
The thermogelling polymers that undergo sol-gel transition in water when the temperature increases, have attracted much attention for various biomedical application. In this work, we synthesized hexanoyl glycol chitosan (HGC) as a new thermogelling polymer by chemical modification of glycol chitosan using hexanoic anhydride. The HGC with degree of substitution of 36% showed a thermo-responsive sol-gel transition around 32 oC. In order to design a chemically cross-linkable thermogelling system, we synthesized methacrylated HGCs (M-HGCs) by the reaction of HGC with glycidyl methacrylate. The degree of methacrylation was controlled to have a range of 5%~19.5%. It was observed that the sol-gel transition temperature slightly decreased with the introduction of hydrophobic methacryl groups. The aqueous solutions of M-HGCs could form thermogel and chemically crosslinked by UV irradiation to demonstrate enhanced mechanical properties. M-HGCs may be useful for various biomedical applications. |
| 저자 |
조익성1, 조명옥1, 이정정1, 강선웅2, 허강무1
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| 소속 |
1충남대, 2안전성평가(연) |
| 키워드 |
Hexanoyl glycol chitosan; Thermogelling; methacrylation; photo-crosslinking; mechanical property
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| E-Mail |
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