| 초록 |
Immunotherapy for certain allergies is used as the only fundamental form of treatment for allergic diseases. Long-term administration of water-soluble antigens produce antibodies, however, a safer and more efficient method is needed. In this study, DerP.1-associated poly(lactic-co-glycolic acid) nanoparticles were produced as a potential vaccine. DerP.1 was immobilized on the PLGA nanoparticle surfaces by EDC/NHS coupling, while the other PLGA nanoparticles contained DerP.1 protein inside. We evaluated the amount of protein release rate, cellular toxicity according to the location of the DerP.1 protein |
