| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 | 28권 1호, p.182 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | The Synthesis and Characterization of biodegradable PU/PEG IPNs |
| 초록 | Biohybridization between cell-polymer becomes common tool to construct artificial organs as a long-term prosthesis. There are two kinds of the biohybrid systems. One is to biohybridize the target cell on the biocompatible and non-degradable polymer surface, and the other is to biohybridize the target cellon the biodegradable polymer scaffold. In the latter system, the polymer is totally substituted by the tissue composed of the grown cells. The first system has the better biological stability of the cells and tissue than the latter system, but has the possibility of producing toxic materials for a long-term usage. And biomaterials must have enough good mechanical strength to endure the repeated stress in human body. In this study, hydrophobic Polyurethane(PU)/hydrophilic Poly(ethylene glycol)(PEG) IPNs were synthesized. The PU prepolymer having biodegradable and biocompatible Poly( -caprolactone) (PCL) was synthesized. The end group (-OH) of PEG was substituted to crosslinkable acrylate group by using Acrylolyl chloride(Ac) and Triethylamine(TEA) to obtain the crosslinkable Poly(ethylene glycol)diacrylate (PEGDA). The amphiphilic IPNs were synthesized by simultaneous polymerization. And the effect of molecular weight of PEG on the biodegradation rate, surface morphology, surface energy and mechanical property was investigated. |
| 저자 | 윤성수;김성철 |
| 소속 | 한국과학기술원 기능성고분자신소재연구센터;한국과학기술원 기능성고분자신소재연구센터 |
| 키워드 | PU; PEG Macromer; PU/PEG IPN |
