| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.354 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | The Mechanism of Anion Selectivity and Gating in Membrane protein: an Atomistic Molecular Dynamics Simulation of Cl– Conduction in ClC channel |
| 초록 | ClC channels are Cl–-selective ion channels that are found in various kinds of organisms from bacteria to humans. In the case of humans, it is known that nine isoforms of ClC channels are involved in various physiological functions, such as the control of the resting potential in muscle and neurons and the acidification process in intracellular organisms. Malfunction and mutation of these channels cause fatal diseases such as myotonias, some types of epilepsy, nephrophathies and osteopetrosis. The two essential properties of ion channels are selective ion conduction and gating. Selective conduction refers to an ability to select one ionic species among those present in the cellular environment and to catalyze its rapid flow through the pore; gating refers to opening and closing the pore, i.e., the process by which ion conduction is turned on or off. Recent success in structural determination of bacterial ClC channel provides us with important insight into ion selectivity and gating1. However, the detailed description about the mechanism of ion selectivity and gating is still far from a complete realization. This paper is thus devoted to elucidate the molecular origins of these functions in ClC channel (selectivity and gating) by means of an atomistic molecular dynamics combined with a perturbation theory. 1. Raimound Dutzler, Ernest B. Campbell, and Roderick MacKinnon, Science, 300, 108 (2003). Fig 1. ions bound to the pore inside ClC channel |
| 저자 | 고연조, 허준, 조원호 |
| 소속 | 서울대 |
| 키워드 | ClC channel; membrane protein; molecular dynamics |
