| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Biological study of biodegradable Poly(propylene carbonate) Prepared from Copolymerization of Carbon Dioxide with Propylene Oxide. |
| 초록 |
We synthesized poly(propylene carbonate) (PPC) films by copolymerization of carbon dioxide with propylene oxide. We investigated bacterial and cell adhesion to PPC in vitro, and biocompatibility and biodegradability in mice. Adhesion of human cells (cell line HEp-2) and five bacterial species [Staphylococcus epidermidis (S. epidermidis), Staphylococcus aureus (S. aureus), Enterococcus faecalis (E. faecalis), Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli)] to PPC films was examined. PPC was also implanted subcutaneously in mice to assess biocompatibility by examining tissue reactions around implant sites and to assess biodegradation causing morphologic changes to the film surface. In addition, in vitro oxidative degradation tests were carried out to understand the mechanism of PPC biodegradation in mice. |
| 저자 |
김진철, 김가희, 박삼대, 김동민, 정정운, 노예철, 안병철, 권원상, 김경태, 김미희, 고용기, 최준만, 정성민, 이문호
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| 소속 |
포항공과대 |
| 키워드 |
poly(propylene carbonate); biodegradation
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| E-Mail |
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