| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 | 28권 2호, p.372 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation of piroxicam patch using skin permeation enhancer |
| 초록 | A monolayer transdermal delivery system for piroxicam has been designed and characterized to achieve adequate flux across the skin with the minimized lag time using the skin permeation enhancer. For this purpose, the systems containing piroxicam with various oils and surfactants were formulated and the permeation studies were performed using Keshary-Chien diffusion cells. The skin was extracted from the abdomen guinea pig skin and hairless mouse and the permeated amount of proxicam was assayed by HPLC. The physical property of the prepared system was examined using peel tester. The optimized formulation for piroxicam patch was established by the consideration of main factors such as enhancers, drug concentration and adhesive. The preliminary result suggests that the optimized formulation in this study can be utilized as a transdermal delivery system of piroxicam. Acknowledgement: This work was supported by KMOCIE |
| 저자 | 길희주1, 강복기2, 정상영3, 육순홍1, 강길선2, 김문석3, 이해방3, 조선행3 |
| 소속 | 1한남대, 2전북대, 3한국화학(연) |
| 키워드 | proxicam; transdermal delivery system |
