| 초록 |
Astaxanthin is considered a powerful antioxidant. However, the efficacy of astaxanthin is limited due to its poor water solubility and stability. To enhance the properties of astaxanthin, 2-hydroxypropyl-γ-cyclodextrin (HP-γ-CyD) can be used through complexation. In this study, we investigated the wound healing ability of astaxanthin/HP-γ-CyD (Ast/HP-γ-CyD) complex in sacran-based hydrogel. HP-γ-CyD played an important role to increase the elastic modulus of the sacran-based hydrogel with high swelling ability. Unusually, the Ast/HP-γ-CyD complex in sacran-based hydrogel provided the highest wound healing ability in mice. These results suggest that the Ast/HP-γ-CyD complex in sacran-based hydrogel has the potential for use as a new transdermal therapeutic system to promote the wound-healing process. |
