| 초록 |
Alzheimer’s disease (AD) is a neurodegenerative disease associated with the loss of nerve cell in areas of the brain and lead to cause death sixthly in 2014. To diagnose AD on early pathological stage, many AD studies focus on the blood-based diagnostic test which is easy to obtain the sample and reflects a change of biomarkers from CSF due to the drawbacks of common tests. Among the rich sources in blood, Amyloid beta1-42, Amyloid beta 1-40, and Tau protein which are closely associated with key mechanism of AD pathology occurring in the brain, are able to be supportive early screening and diagnostic tools. Here, we are developing the multi-detection biosensor of those markers based on Rayleigh scattering and colorimetric assay depended on plasmonic properties of AuNPs. Also, we did pre-treatment with chaotropic agent which interfere the binding between biomarkers and other plasma protein to increase the detection limit. |
