| 초록 |
pH-Controlled assembly systems have been widely explored, and their applicability in the area of drug delivery has been suggested. We describe here polymer-mediated reversible assembly systems consisting of poy(ε-caprolactone)-b-poly(carboxylic acid)s micelles with ionizable shells and proton-accepting polymers. As pH decreased from 7.4 to 2.0, the mixture of the polymers and the polymer micelles underwent a unique three-stage phase transition: Single micelles, initiation of polymer-mediated micelle assembly, and formation of solid hybrid. This pH-dependent assembly was a reversible process. The detailed study on pH-controlled reversible assembly was carried out using fluorescence spectroscopy and dynamic light scattering. Acknowledgement. This research was supported by a grant (code #: 05K1501-01510) from 'Center for Nanostructured Materials Technology' under '21st Century Frontier R&D Programs' of the Ministry of Science and Technology, Korea. |
