| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Two Year Follow-Up for Bone Regeneration of Dual Growth Factors-Immobilized Polycaprolactone Porous Beads Using Mini-Pig Model |
| 초록 |
Sufficient reconstruction of bony defect caused by fraction, tumor resection, and skeletal deformities is often essential. Recently, autologous transplantation of cortical and cancellous bones have been considered as a gold standard for the bone regeneration, however, donor site morbidity and limited availability of donor materials are still remained as significant challenges in clinical fields. To overcome these limitations, we prepared human periosteum-derived osteoblasts seeded into growth factors (BMP-2 and/or VEGF)-releasing polycaprolactone (PCL)/Pluronic F127 porous beads. The Pluronic F127 molecules exposed on the pore surfaces of the bead act as an intermediary between the PCL pore surface and heparin that can interact with the growth factors. The bone regeneration behaviors of the growth factors-immobilized PCL beads were investigated for 2 years using a miniature pig model. |
| 저자 |
이진호1, 오세행2, 김태호1, 변준호3, 박미리1
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| 소속 |
1한남대, 2단국대, 3경상대 |
| 키워드 |
Polycaprolactone; Porous Beads; Dual Growth Factors; miniature pig model
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| E-Mail |
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