| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
콜로이드 및 분자조립 부문위원회 I |
| 제목 |
Magnetically separated multi-detecting SERS system for diagnosing overexpressed circulating miRNA of pancreatic cancer in serum |
| 초록 |
Pancreatic cancer is hard to cure, but can be treated when it is found early. So, early detection of pancreatic cancer is a significant key in cancer therapy. SERS is a promising tool for detecting single molecule in sample. We focused on rapid separating and detecting circulating miRNA of pancreatic cancer in blood serum. Here, magnetic nanocluster (MNC) capped with silica was functionalized with 2 nm gold nanoparticle (MNC@Si@Au) to increase its colloidal stability during miRNA conjugation and separation. Then, plasmonic-enhancing gold nanoparticle was employed to increase miRNA probe Raman signal. SERS signal of the system was successfully collected in blood-serum mimic system. |
| 저자 |
안윤선1, 함승주1, 김진영1, 문병걸1, 강병훈2
|
| 소속 |
1연세대, 2한국생명공학(연) |
| 키워드 |
miRNA detection; pancreatic cancer; SERS
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| E-Mail |
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