| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Optical Molecular Imaging of Atheroma Inflammation with a Novel, Mannose Receptor Targeting Near-infrared Fluorescence Probe in Genetically Engineered Mice and Atheromatous Rabbits |
| 초록 |
A novel NIRF probe was fabricated by chemically conjugating glycol chitosan with mannose-PEG, cholesterol and NIRF dyes such as Cy5.5 for mouse imaging and Cy7 for rabbit imaging. In vitro, NIRF probe was selectively uptaken by RAW264.7 cells, and NIRF signals were estimated to be 10-fold over control group. Plaque macrophage NIRF signals were prominently enhanced in carotid artery of apoE -/- mice by multispectral laser confocal fluorescence imaging in vivo, and in coronary sized vessels of atheromatous rabbits by fluorescence reflectance imaging, which were induced by balloon induced endothelial denudation with a high-cholesterol diet for 12 weeks. Our newly developed mannose receptor targeting NIRF probe was able to selectively target and image macrophage-rich atheromata both in the mice artery and in coronary sized rabbit vessels. |
| 저자 |
박경순1, 김지박2, 이재중2, 박옥규1, 송준우2, 유홍기3, 오왕열4, 김진원2
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| 소속 |
1한국기초과학지원(연), 2고려대, 3한양대, 4한국과학기술원 |
| 키워드 |
Atheroma inflammation; Optical molecular imaging; Near-infrared fluorescence probe; Mannose receptor
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| E-Mail |
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