| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Injectable Hyaluronic Acid Hydrogels for the Treatment of Rheumatoid Arthritis |
| 초록 |
Injectable tyramine modified hyaluronic acid (HA-Tyr) hydrogels were successfully developed for the treatment of rheumatoid arthritis (RA) with reactive oxygen species facilitating the hydrogel formation. HA-Tyr hydrogels were prepared for the encapsulation of dexamethasone (DMT) as a model RA drug by radical crosslinking reaction using hydrogen peroxide and horse radish peroxidase. According to in vitro release tests, DMT was sustained released from the HA-Tyr hydrogels up to a month. Intra-articular injection of the injectable HA-Tyr hydrogels encapsulating DMT resulted in successful treatment of RA with statistically significant reduction of IL-6, PGE2 and other cytokine levels in collagen-induced arthritis animal models. Histological analysis with hematoxylin & eosin staining also confirmed the therapeutic effect of injectable HA-Tyr hydrogel systems. The recovered cartilage after treatment with HA-Tyr hydrogels containing DMT was comparable to that of normal SD rats. |
| 저자 |
김기수, 고은지, 한세광
|
| 소속 |
포항공과대 |
| 키워드 |
Hyaluronic acid; Tyramine; Hydrogel; Dexamethasone; Rheumatoid Arthritis |
| E-Mail |
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