| 초록 |
One of the unique structural features of Mussel adhesive proteins (MAPs) is the presence of L-3,4-dihydroxyphenylalanine (DOPA) which is believed to be responsible for the adhesive characteristics of MAPs. For the underwater adhesives with biocompatible and more flexible bonds using biomimetic adhesive groups, DOPA-like adhesive molecules were modified with cyanoacrylates to obtain different repeating units and chain length copolymers. The goal of this work is to copy the mechanisms of underwater bonding to create synthetic water-borne underwater medical adhesives through blending of the modified DOPA and a triblock copolymer (PEO-PPO-PEO) for practical application to repair wet living tissues and bones, and in turn, to use the synthetic adhesives to test mechanistic hypotheses about the natural adhesive.
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