| 초록 |
Reactive Oxygen Species (ROS) have been caused to many diseases, aging, obesity in human body. To solve these issues, antioxidant agent as natural substance, to have the anti-oxide, anti-aging, anti-cancer and low toxic, has been used for protection of ROS. However, it has a problem such as very a low bioavailability in body and high toxicity. To overcome these problems, we prepared to antioxidant agent-encapsulated chitosan microsphere (AECM) by using spray dry method. Its structural analysis of AECM was confirmed by 1H-NMR. Also, The encapsulation efficiency of antioxidant agent from AECM was analyzed by UV-Vis spectrophotometer. Additionally, morphological property of AECM was observed by SEM, which had a spherical shape and particle size of 2 ~ 5 ㎛. In addition, its cytotoxicity was evaluated by MTT assay. These results suggest that AECM can apply as antioxidant agent with low toxicity and improved bioavailability. (NRF-2016H1D5A1910499). |
