| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Biocompatible polymers-coated magnetic nanoparticles as ultra sensitivecontrast agent. |
| 초록 |
Biocompatible polymer nanoparticles containing a cluster of manganese-doped superparamagnetic nanoparticles(Mn-SPIONs) were simply fabricated by ionic assembly between poly-γ-glutamic acid(γ-PGA) and chitosan. Mn-SPIONs coated with hydrocarbon molecules were synthesized via thermal decomposition method. Mn-SPIONs were transferred into aqueous phase via ligand exchange with γ-PGA. Polymer nanoparticles were formed by ionic assembly between negative charged γ-PGA coated Mn-SPIONs and positive charged chitosan, and the size of particles was 80~150nm, confirmed by SEM, TEM and DLS. Polymer nanoparticles presented high value of MRI relaxivity, 507(Mn+Fe) mM-1S-1, which is much higher than that of conventional iron oxide-based MRI contrast agents, due to their synergic magnetism effect. These nanoparticles were easily taken up by RAW 264.7 cells, and it was confirmed by prussian blue staining and a strong darkening effect of T2-based MR images of Mn-SPIONs labeled RAW 264.7 cells. |
| 저자 |
김현민1, 이정은1, 조미영1, 홍관수2, 임용택1
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| 소속 |
1충남대, 2한국기초과학지원(연) |
| 키워드 |
MRI; biocompatigble polymer; magnetic nanoparticle
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| E-Mail |
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