| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Fabrication of PAH/DP Nanocapsules Containing SPIONs for Cancer Theragnosis |
| 초록 |
Photodynamic therapy (PDT) is a promising method for the treatment of several cancers. It involves the systemic administration of photosensitizers like porphyrin. In this work, a 3rd generation dendrimer porphyrin (DP) with 32 carboxyl groups on the periphery was used as a component for a layer-by-layer structure. To enhance the efficacy and tumor-specificity of PDT, poly(allylamine hydrochloride) (PAH) / DP nano-sized capsule was constructed through a LbL self-assembly on a removable template. Moreover, multifunctional nanocapsule was fabricated that is capable to diagnose cancer cells using MR contrast agent by containing superparamagnetic iron oxide nanoparticles(SPIONs) on nanocapsules with PDT effect. Finally, the agent for surface modification could be coated onto the nanocapsules through electrostatic interaction between DP and Polyethylene glycol (PEG). Thus, diagnosis and treatment of cancer cells were implemented after injecting the nanocapsules into the cancer cells. |
| 저자 |
정의석, 윤희재, 박상필, 장은지, 이현종, 한상원, 장우동, 고원건
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| 소속 |
연세대 |
| 키워드 |
Layer-by-Lyaer; Theragnosis; Photodynamice therapy; SPIONs
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| E-Mail |
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