| 학회 |
한국재료학회 |
| 학술대회 |
2020년 가을 (11/18 ~ 11/20, 휘닉스 제주 섭지코지) |
| 권호 |
26권 1호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Small-diameter decellularized vascular grafts reinforced with electrospun polycaprolactone |
| 초록 |
Small-diameter vascular grafts (SDVGs) comprised of decellularized extracellular matrix (ECM) and electrospun polycaprolactone (PCL) were generated for potential cardiovascular applications with higher mechanical properties. Rat aortas were successfully extracted and decellularized resulting to lower DNA content compared to native vessels. Results showed increased tensile properties of decellularized ECM upon the addition of electrospun PCL fibers. The PCL-ECM grafts were devoid of delamination through solution immersion of the ECM lining. In vitro studies provided that PCLECM scaffolds were biocompatible, showed minimal hemolysis, and low blood coagulation behavior. Overall, SDVGs were easily generated which has potential for in vivo allogenic applications. |
| 저자 |
John Patrick Cuenca1, Andrew Padalhin2, Byong-Taek Lee3
|
| 소속 |
1Department of Regenerative Medicine, 2College of Medicine, 3Soonchunhyang Univ. |
| 키워드 |
Electrospinning; vascular graft; decellularization; ECM; PCL
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| E-Mail |
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