| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I: Recent Advances in Theranostic Macromolecules |
| 제목 |
Enhanced intra-tumoral blood perfusion by orally active low molecular weight heparin |
| 초록 |
We verified in this study that prevention of CAT by administering orally available low molecular weight heparin (STP3725) substantially improved tumor perfusion and alleviated hypoxia. We confirmed that treating STP3725 significantly potentiated the efficacy of oxaliplatin and gemcitabine by enhancing the drug delivery and distribution in the tumor tissue. Furthermore, we identified that administering STP3725 altered tumor microenvironment into immuno-supportive one by augmenting effector lymphocytes population, decreasing hypoxia related immunosuppressive cytokines and myeloid derived suppressor cells (MDSCs) and these favorable changes markedly benefited the anti-tumor efficacy of anti-PD-1 antibody. Collectively, our findings establish the rationale for a new potential combination strategy, which could be broaden to a combination of anticoagulation therapy with other chemotherapeutic and immunotherapeutic agents. |
| 저자 |
변영로 |
| 소속 |
서울대 |
| 키워드 |
Heparin; oral delivery; perfusion; hypoxia; immunotherapy
|
| E-Mail |
|
