| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Folic acid-functionalized polythiophene for targeted cellular imaging |
| 초록 |
Polythiophene containing pendent N-hydroxysuccinimide (NHS) ester groups was reacted with poly(ethylene glycol) (PEG) and oleylamine, which was subsequently modified with folic acid to prepare a targeted fluorescent cellular imaging probe. The amphiphilic character of the folic acid-functionalized polythiophene induced the formation of nanoparticles in water with an average diameter of 95.3 nm. This polymer shows good photostability and little toxicity to KB cells at a high concentration (100 ug/mL), which meets the crucial requirement for cellular imaging and other biological applications. The folic acid-functionalized polythiophene could be internalized efficiently into KB cells and accumulated in the cytoplasm to give bright fluorescence, indicating that it is good candidate for fluorescence imaging of living cells. |
| 저자 |
김현철1, 김은주1, 이세근1, 이성준1, 정상원1, 하태린1, 이승우2
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| 소속 |
1대구경북과학기술원, 2영남대 |
| 키워드 |
: Polythiophene; Amphiphiles; Nanoparticles; Cell imaging
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| E-Mail |
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