| 초록 |
Encapsulation of active agents is of great importance in the fields of drug delivery and bioreactors. A useful platform that is practically applicable is a microshell system, which is typically achieved either by self-assembly of amphiphiles, or by generation of a thin composite shell layer. Such microshell systems are indeed advantageous because they enable easy capture of active agents in the core which is protected again by the mechanically robust shell layer. However, most of shells are made with organic or hybrid organic phases, so that leakage of small active molecules inevitably occurs. To overcome this problem, we propose a new microshell system, in which polycaprolactone microparticles are coated with multi-layered silica nanoparticles/polyelectrolyte shells. Then, we show that the presence of silica nanoparticles in the polyelectrolyte shell layer play an essential role in remarkably improving the shell impermeability. This is experimentally demonstrated by evaluating the molecular deformation of an oxygen sensitive model antioxidants, retinol. |
