| 학회 |
한국화학공학회 |
| 학술대회 |
2018년 가을 (10/24 ~ 10/26, 대구 EXCO) |
| 권호 |
24권 2호, p.1477 |
| 발표분야 |
생물화공(Biochemical Engineering) |
| 제목 |
Target Lipophilic Drug Carrier Using Oleosome for Cancer Treatment |
| 초록 |
Until now, since numerous potent lipophilic drugs show low bioavailability, lipophilic drugs cannot be delivered by intravenous injection or oral. In this research, to overcome the limitations of the lipophilic drug delivery, the magnetic oleosome functionalized with recombinant proteins is developed as a new carrier of oil-based lipid drugs for cancer treatment. Proposed oleosome consists of neutral fats by a phospholiqid single layer with embedded oleosin fusion proteins. The oleosin is genetically fused to a nanobody of a fluorescent protein (FP). The oleosome is coupled to antibody using a recombinant protein composed of immunoglobulin-binding protein LG fused to FP for delivery targeted to breast cancer cells. In addition, the lipid core of oleosome contained magnetic nanoparticles and carmustine as lipophilic drugs. Specific delivery of oleosome to target cancer cells is investigated through a confocal microscope. Also, oleosome is effective in cancer cells treatment by animal study. From result, this lipophilic drug loaded magnetic oleosome can be an effective tool for lipophilic drug delivery for cancer treatment. |
| 저자 |
김동연1, 조현열1, 이 택2, 윤진호1, 최정우1
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| 소속 |
1서강대, 2광운대 |
| 키워드 |
생물화공 |
| E-Mail |
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| 원문파일 |
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