| 초록 |
Biological systems have the potential to offer solutions for urgent challenges from energy, environment, and human health. Engineering biological systems, however, frequently involves screening of extremely large solution space to discover useful phenotypes such as proteins with new functions or metabolic pathways for chemical production. In this talk, I am going to introduce examples showing how synthetic biology can provide new avenues for evolutionary bioengineering, focusing on the metabolic engineering of microorganisms. Particularly, the development and applications of artificial regulatory RNAs will be discussed which were utilized as intracellular sensors to guide the evolution of metabolite-producing bacteria. Additionally, a synthetic biology platform for rapid diagnosis of pathogens called SENSR will be discussed. |
