| 초록 |
Photodynamic therapy (PDT) has emerged as an innovative therapeutic method for treating various oncological diseases, including cervical cancer. PDT can convert oxygen into reactive oxygen species (ROS) to suppress tumor growth by using photosensitizer under laser irradiation. Generated ROS can cause significant toxicity leading to cell death via apoptosis. In this study, we report herein on the systhesis of hydrophilic polymeric nanoparticles (PPHE) consisted of Pheo a, γ-polyglutamic acid, amphiphilic Poly(L-lactide–co-glycolide)–poly(ethylene glycol) (PLGA–mPEG), hyaluronic acid and HPV16 E7 analogues (PEG2-TLGIVCPI). In addition, cold atmospheric plasma (CAP) was applied to the cervical cancer therapy to improve therapeutic efficacy. Finally produced PPHE can lead to high cancer cell death rate through PDT and CAP combination therapies. |
