| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Development of Cardiogreen-Polymer Dot Encapsulated by Silica Nanoparticle for Cancer Cell Imaging Probe and Photothermal Therapy |
| 초록 |
Nanoparticles involving intermolecular interaction between cardiogreen (ICG) and fluorescence polymer dot (PD) as pH-responsive fluorescence nanoparticle to detect cancer cells and near-infrared (NIR) controllable photothermal therapy (PTT) was designed. Interaction between ICG and PD is employing the electrostatic interactions between the quaternary amine of the PD with ICG (SO3-) while the hydrophobic side will undergo hydrophobic interaction and π-π stacking with the PD's aliphatic chain. ICG/PD-MSN displayed a pH-sensitive response which promotes the release of ICG when exposed to acidic environment distinguished it from physiological condition. ICG/PD-MSN exhibited pH-dependent photon to heat conversion which adequate enough to kill cancer cell in acidic pH. |
| 저자 |
베니, 박성영
|
| 소속 |
한국교통대 |
| 키워드 |
mesoporous silica nanoparticles; polymer dot; bioimaging; pH-sensitive; photothermal
|
| E-Mail |
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