| 초록 |
In this report, we present heparinized fibrous particle (HFP) as a novel growth factor delivery system. The particles were prepared by aminolysis of poly(L-lactide) nanofiber, and heparin was easily conjugated to the particles. The HFPs have over 10 um length and 700 nm in diameter, and showed approximately 40% loading efficiency of vascular endothelial cell growth factor (VEGF). As the VEGF-bound HFPs were incorporated within alginate hydrogel, only half of VEGF was released from the HFP-loaded hydrogel as compared to alginate hydrogel for 28 days. Furthermore, the released VEGF successfully promoted the proliferation of human mesenchymal stem cells. Therefore, a fibrous particle can be an alternative growth factor delivery tool for tissue engineering. |
