| 초록 |
Recently, chitosan has the ability as not only drug carriers but also non-viral vector for gene delivery because of its high positive charges and low cytotoxicity. Therefore, chitosan will emerge as an important biomedical material of the 21st century. Untill now, high molecular weight chitosan (HMWC) modified with water soluble moieties have been used but it include some problems such as absorption in the body. In this study, we prepared ultra low molecular and water soluble chitosan (ULMWSC) with free amine group and its structural characters were investigated using FT-IR, 1H-NMR, 13C-NMR, GPC and MALDI-TOF Mass spectrometer etc. Resultantly, the character of the pure ULMWSC was quantitatively analyzed by these results. Also, the potential as biomaterial was studied through the animal experiment.
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