| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Fabrication, AFM Imaging and Electrical Signal Analysis of Si-Nanowire Field Effect Transistor Aptamer Biosensor |
| 초록 |
We report the fabrication, AFM imaging and electrical signal analysis of Si nanowire field-effect transistor (SiNW-FET) aptamer biosensor. Surface modifications were carried out using 3-aminopropyl diethoxysilane and succinic anhydride to introduce amine and carboxyl groups on Si-NW. Aptamers with 5’-end amine groups were chemically grafted on the surface-modified Si substrates through the amide bond formation. Atomic force microscopic analysis confirmed the successful immobilization of aptamers on Si nanowire and the following protein binding to the aptamers. Furthermore, fluorescence micrograph clearly visualized the attached protein to aptamers immobilized on Si-NW. The Si-NW aptamer biosensor was successfully applied for the real-time detection of electronic signals during and after protein binding. |
| 저자 |
김기수, 이현승, 조문호, 한세광
|
| 소속 |
포항공과대 |
| 키워드 |
Aptamer; Si-Nanowire; Surface modification; Electrical detection; Aptamer biosensor
|
| E-Mail |
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