| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Dual-Responsive Hybrid Fluorescent Nano Probe Based on Graphene Oxide with Functionalized Polymer for Cancer Cell Imaging |
| 초록 |
We have developed a pH- and thermo-responsive fluorescent nanomaterial of functionalized reduced graphene oxide (rGO) with cross-linked polymer produced via catechol-boronate diol binding mechanism. When conjugated with the hydrophobic dye boron dipyrromethane (BODIPY), this material can act as a dual-responsive nanoplatform for detection of cells. The rGO was synthesized by reducing GO with catechol group in the cross-linked polymer, which then able to stabilize the quenching mechanism of nanomaterials. This nanoplatform exhibits intense fluorescence at acidic pH and low fluorescence at physiological pH which later proved by confocal laser scanning microscopy (CLSM) images. Therefore, we have successfully developed a promising sensitive bio-imaging probe for identifying cancer cells. This was supported by Korea National University of Transportation in 2016. |
| 저자 |
Khoerunnisa, 박성영
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| 소속 |
한국교통대 |
| 키워드 |
pH- and thermo-responsive; fluorescent nanomaterials; catechol chemistry
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| E-Mail |
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