| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
A Bio-inspired Swellable Microneedle Adhesive for Mechanical Interlokcing with Tissue |
| 초록 |
Achieving significant adhesion to soft tissues while minimizing tissue damage poses a considerable clinical challenge. Here inspired by the endoparasite Pomphorhynchus laevis, which swells its proboscis to attach to its host’s intestinal wall, we have developed a biphasic microneedle array that mechanically interlocks with tissue through swellable microneedle tips, achieving ~3.5-fold increase in adhesion strength compared with staples in skin graft fixation, and removal force of ~4.5 N cm−2 from intestinal mucosal tissue. Comprising a poly(styrene)-block-poly(acrylic acid) swellable tip and non-swellable polystyrene core, conical microneedles penetrate tissue with minimal insertion force and depth, yet high adhesion strength in their swollen state. Uniquely, this design provides universal soft tissue adhesion with minimal damage, less traumatic removal, reduced risk of infection and potential for delivery of bioactive therapeutics. |
| 저자 |
양승윤1, Eoin D. O'Cearbhaill2, Geoffroy Sisk3, Kyeng Min Park4, Woo Kyung Cho2, Martin Villiger5, Brett Bouma6, Bohdan Pomahac7, Jeffrey Karp8
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| 소속 |
1부산대, 2Brigham and Women’s Hospital, 3Harvard Medical School, 4Division of Plastic Surgery, 5Harvard Univ., 6Massachusetts Institute of Technology, 7Wellman Center for Photomedicine, 8Massachusetts General Hospital |
| 키워드 |
Tissue adhesive; Microneedle; Biomimicry; Mechanical interlocking
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| E-Mail |
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