| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
PCL/HA Hybrid Microspheres as a Bone Substitute Material |
| 초록 |
Polycaprolactone (PCL) is widely used as a bone substitute (graft) material, however, it poses poor tissue compatibility and osteoconductive capacity for bone regeneration. HA is a naturally produced non-immunogenic glycosaminoglycan and plays a significant role as a facilitator of osteogenesis for stem cells. We fabricated PCL/HA hybrid microspheres by a spray/precipitation method using a double nozzle spray. To investigate the bone regeneration behavior of PCL/HA microspheres, we used SD rat with a calvarial defect. From the animal study for bone regeneration using a calvarial defect model of SD rat for 4 and 8 weeks, it was observed from the analyses of micro-CT and Masson's trichrome staining that the PCL/HA hybrid microsphere group showed more enhanced bone regeneration than the PCL microsphere group, even after 4 weeks. PCL/HA hybrid microspheres can be a promising bone substitute material compared to the PCL microspheres without HA. |
| 저자 |
신준영1, 장희윤1, 김세현1, 변준호2, 오세행3, 이진호1
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| 소속 |
1한남대, 2경상대, 3단국대 |
| 키워드 |
Polycarprolactone; Hyaluronic acid; Microsphere; Bone regeneration
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| E-Mail |
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