| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.119 |
| 발표분야 | 생체적합성 유ㆍ무기 입자소재 |
| 제목 | Polymeric micelles as biocompatible drug carriers |
| 초록 | A polymeric micelle drug carrier system is a supramolecular assembly of polymers typically forming from an AB type of block copolymers, and drugs are incorporated into the inner core, as shown in Fig. 1. For drug targeting purposes, a polymeric micelle possessing a hydrophobic inner core and a hydrophobic outer shell is most commonly used because most drug molecules have a hydrophobic moiety(ies) and because the hydrophobic inner core is an appropriate reservoir of the hydrophobic drug molecules. The polymeric micelle drug carrier systems show several strong advantages as compared with the other types of drug carriers such as conventional (non micelle-forming) polymers, liposomes, micro(nano)spheres, and emulsions. These advantages are very small size (10 to 100 nm in diameter), high structural stability in physiological conditions, high water solubility, large capacity for drug loading, and low toxicity. Owing to these advantages, polymeric micelles can successfully target drugs to the therapeutic sites. Presently, two polymeric micelle formulations are in clinical trials in Japan for targeting anti-cancer drugs to solid tumors. Biocompatibility is an essential matter for drug carriers as well as for the other biomaterials. A term biocompatibility used for drug carrier contains a little different aspect from that used for the other biomaterials. Physico-chemical properties of drugs very often lower drug targeting efficiency by enhancing unfavorable delivery to the reticuloendothelial systems (e.g., liver and spleen) due to hydrophobic and/or positively charged characters of the drugs. If drug carriers can conceal such unfavorable properties of drugs in them, the drug targeting efficiency is not lowered by the incorporated drug, and the carrier systems can be called “biocompatible”. This paper focuses on molecular design of “biocompatible” polymeric micelles for successful drug targeting using two anti-cancer drugs, doxorubicin and camptothecin as incorporated drugs. |
| 저자 | Masayuki Yokoyama |
| 소속 | Kanagawa Academy of Science and Technology |
| 키워드 | |
