| 학회 |
한국재료학회 |
| 학술대회 |
2018년 봄 (05/16 ~ 05/18, 삼척 쏠비치 호텔&리조트) |
| 권호 |
24권 1호 |
| 발표분야 |
B. 나노화학/바이오 분과 |
| 제목 |
In-vitro and in-vivo evaluation of hemostatic potential of decellularized ECM hydrogels |
| 초록 |
Extracellular matrix (ECM) hydrogels with a porous microstructure and good swelling behavior were fabricated via lyophilization and cross-linked with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC). Platelet adhesion studies revealed that platelets readily adhered to hydrogels while coagulation studies showed rapid blood aggregate formation on the hydrogels and hemolysis studies showed that the hydrogels are non- hemolytic in nature. In-vitro cytotoxicity studies showed ECM hydrogels are cytocompatible and can support adhesion and proliferation of L929 cells after 1 and 7 days based on fluorescence staining. In-vivo studies using rat tail bleeding and rabbit arterial injury showed ECM hydrogels' ability in hemostasis. ECM hydrogels formed a physical barrier and activated platelets that resulted in rapid thrombin formation during in-vivo application. The present study revealed ECM hydrogels could be a potential biomaterial for hemostat application. |
| 저자 |
Reiza D. Ventura1, Byong Taek Lee2
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| 소속 |
1Department of Medicine, 2Collge of Medicine |
| 키워드 |
Extracellular matrix; hydrogel; hemostat; porcine skin; hemostat hydrogel
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| E-Mail |
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