| 초록 |
Poly(ε-caprolactone) (PCL) has been widely used as biodegradable polymer due to its good drug permeability and biocompatibility. But the application of PCL for drug delivery has a drawback of slow degradation rate in vivo due to its high crystallinity and hydrophobicity. Enhancement of hydrophilicity of PCL has been achieved by the chemical addition of a hydrophilic moiety, such as poly(ethylene oxide) (PEO). In this study, the effect of different contents of PEO for the diameter and form of the nanocapsules is observed by image analyzer and scanning electron microscopy (SEM). The molecular interactions of the wall (PCL/PEO) and core materials (drug) are determined from the mean contact angles. The drug release behaviors of PCL/PEO nanocapsules are characterized by UV/vis. spectra in ethyl alcohol. As a result, the mean diameter of prepared nanocapsules is 170∼180 nm and spherical forms are observed by image analyzer and SEM. Drug release rate of nanocapsules is increased with increasing the content of PEO.
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