| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Anti-fouling characteristics of telechelic Rf-PEG monolayers at the air/water interface |
| 초록 | Poly(ethylene glycol)s (PEGs, 6K or 10K g/mol) terminated at both ends by hydrophobic fluoroalkyl segment (-(CH2)2C10F21) have been demonstrated to self-assemble into essentially water insoluble hydrogels1 . Here, we characterized the monolayers formed by these Rf-PEGs and the protein adsorption as a function of the monolayer packing density at the air/water interface using thermodynamic methods, neutron reflectivity and fluorescence microscope. First, the π-A isotherm of Rf-PEGs showed two plateaus. The first plateau was attributed to the conformational change of PEG chains form from a pancake-like shape to a stretched shape; by compression, hemispherical micellar PEG clusters at the surface are stretched into the subphase. The second plateau resulted from submerging of the micellar Rf-PEGs into the subphase upon further compression, leading to a multiplayer state. Second, we analyzed the FITC-BSA adsorption onto the Rf-PEG monolayers at various packing states in-situ. Before the 1st transition that represents freely floating hemispherical Rf-PEG micelles, the Rf-PEG did not suppress the protein adsorption efficiently. On the other hand, only a negligible amount of protein was adsorbed onto the Rf-PEG monolayer after the 1st transition state. Acknowledgement This research was supported by a grant (code #: 05K1501-00110) from 'Center for Nanostructured Materials Technology' under '21st Century Frontier R&D Programs' of the Ministry of Science and Technology, Korea. Reference 1. G. Tae, J. A. Kornfield, J. A. Hubbell, D. Johannsmann, T. E. Hogen-Esch, Macromolecules 34 6409 (2001) |
| 저자 | 양호성, 신관우, 태기융 |
| 소속 | 광주과학기술원 |
| 키워드 | Rf-PEG; neutron reflectivity; air/water interface; protein adsorption; monolayer |
