| 초록 |
Polymeric colloidal particles gain much interest recently as effective candidates for drug delivery carriers. In particular, since the microvasculature pore size of tumors ranges from ＞200 nm, while that of healthy vasculature is only ＜ 10 nm, drug bearing colloidal particles with specific sizes can be directly used for anticancer drug targeting carriers with a selective permeability into the target cells. Yet, enhancement of permeability into the target cells is still a big issue, because medical treatment requires a certain level of accumulation. In this regard, the size and surface properties of the colloidal particles for biological application should be clarified. In this presentation, we prepared various sizes of PS colloid particles bearing an accurately controlled charge density by attaching ion-containing random copolymers (ionomers) onto size-selective PS colloidal particles. As the mol% of charge density of the ionomers increases, the modified PS particles showed an progressive increase in the zeta - potential of aqueous dispersions, ranging from -25 mV to – 50 mV. In order to understand the size and charge effect in biological systems, we used these particles as a model system for an intracellular drug delivery carrier, and analyzed the intracellular transport properties depending on the size and the charge of the nanoparticles. |
