| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Enzyme-mediated injectable hydrogel for tissue engineering and drug delivery |
| 초록 |
Recently, injectable hydrogel systems using end-group-chemical reaction have been widely investigated. In particular, enzymatic cross-linking systems using horseradish peroxidase (HRP) and hydrogen peroxide (H2O2) have some advantages, such as biocompatible and fast reaction in mild condition. In this study, injectable hydrogels composed of Tetronic-tyramine (Tet-TA), gelatin-hydroxyphenylacetic acid (GHPA) and heparin-tyramine (Hep-TA) conjugates were developed. The conjugates were synthesized by a common carbodiimide/active ester-mediated coupling reaction. The hydrogels were rapidly formed under physiological condition in presence of HRP and H2O2. Their physico-chemical properties were characterized and in vitro cell culture was investigated using osteoblast. In addition, in vitro growth factor release test was carried out. Obtained results demonstrated that the enzyme-mediated injectable hydrogel is a promising injectable material for tissue engineering and drug delivery. |
| 저자 |
박경민1, 신영민2, 정윤기1, 신흥수2, 박기동1
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| 소속 |
1아주대, 2한양대 |
| 키워드 |
Injectable hydrogel; enzymatic reaction; tissue engineering; drug delivery
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| E-Mail |
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